Mechanobiological oscillators control lymph flow
Identifieur interne : 001B06 ( Main/Exploration ); précédent : 001B05; suivant : 001B07Mechanobiological oscillators control lymph flow
Auteurs : Christian Kunert ; James W. Baish ; Shan Liao ; Timothy P. Padera ; Lance L. MunnSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2015.
Abstract
Dysfunction of lymphatic drainage results in significant morbidity in millions of patients each year, and there are currently no pharmacological treatments available. Because a mechanistic understanding of lymphatic control has been elusive, it has not been possible to develop effective, targeted therapies to alleviate lymphedema or facilitate immune cell trafficking in lymphatic pathologies. Here, we show that complementary biological oscillators control lymphatic transport, driven by mechanosensitive calcium and nitric oxide (NO) dynamics. The mechanism shows fascinating adaptability and autoregulation, inducing active pumping of the lymphatic vessels when gravity opposes flow, but vessel relaxation when pressures are able to drive flow passively.
Url:
DOI: 10.1073/pnas.1508330112
PubMed: 26283382
PubMed Central: 4568261
Affiliations:
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Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital<institution>Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02114;</nlm:aff></affiliation></author><author><name sortKey="Baish, James W" sort="Baish, James W" uniqKey="Baish J" first="James W." last="Baish">James W. Baish</name><affiliation><nlm:aff id="aff2">Biomedical Engineering and Mechanical Engineering,<institution>Bucknell University</institution>, Lewisburg,<addr-line>PA</addr-line> 17837</nlm:aff></affiliation></author><author><name sortKey="Liao, Shan" sort="Liao, Shan" uniqKey="Liao S" first="Shan" last="Liao">Shan Liao</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital<institution>Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02114;</nlm:aff></affiliation></author><author><name sortKey="Padera, Timothy P" sort="Padera, Timothy P" uniqKey="Padera T" first="Timothy P." last="Padera">Timothy P. Padera</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital<institution>Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02114;</nlm:aff></affiliation></author><author><name sortKey="Munn, Lance L" sort="Munn, Lance L" uniqKey="Munn L" first="Lance L." last="Munn">Lance L. Munn</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital<institution>Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02114;</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Dysfunction of lymphatic drainage results in significant morbidity in millions of patients each year, and there are currently no pharmacological treatments available. Because a mechanistic understanding of lymphatic control has been elusive, it has not been possible to develop effective, targeted therapies to alleviate lymphedema or facilitate immune cell trafficking in lymphatic pathologies. Here, we show that complementary biological oscillators control lymphatic transport, driven by mechanosensitive calcium and nitric oxide (NO) dynamics. The mechanism shows fascinating adaptability and autoregulation, inducing active pumping of the lymphatic vessels when gravity opposes flow, but vessel relaxation when pressures are able to drive flow passively.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Baish, James W" sort="Baish, James W" uniqKey="Baish J" first="James W." last="Baish">James W. Baish</name><name sortKey="Kunert, Christian" sort="Kunert, Christian" uniqKey="Kunert C" first="Christian" last="Kunert">Christian Kunert</name><name sortKey="Liao, Shan" sort="Liao, Shan" uniqKey="Liao S" first="Shan" last="Liao">Shan Liao</name><name sortKey="Munn, Lance L" sort="Munn, Lance L" uniqKey="Munn L" first="Lance L." last="Munn">Lance L. Munn</name><name sortKey="Padera, Timothy P" sort="Padera, Timothy P" uniqKey="Padera T" first="Timothy P." last="Padera">Timothy P. Padera</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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